Low-Temperature Magnesium Calcium Phosphate Ceramics with Adjustable Resorption Rate

Low-temperature ceramics based on magnesium calcium phosphate cement are a promising resorbable material for bone tissue restoration with the possibility of functionalization. The replacement Mg2+ ion Ca2+ at stage preparation precursor leads to production multiphase containing phases brushite, monetite, and newberyite, different dissolution rates. Multiphase volumetric resorption preservation their geometric shape, which was confirmed by results an evaluation output ions into contact solution X-ray density ceramic samples during subcutaneous implantation. combined introduction sodium pyrophosphate decahydrate citric acid monohydrate as setting inhibitors neutralizes insignificant negative effect physico-chemical properties (strength, pH, porosity), determining optimal composition. In vivo experiments in composition showed biological response, affecting rate par ions. Preliminary data biocompatibility solubility determined magnesium-calcium additives that regulate be potential vector further research, including orthotopic implantation models.